Design, synthesis, and biological evaluation of novel derivatives of marine natural product ammosamide B
An improved method for synthesis of ammosamide B and its derivatives from commercially available 6-chloroisatin was explored. Systematic structural modifications based on ammosamide alkaloids were carried out and the structure-activity relationship of anti-TMV activity was summarized. Compound 13a, exhibiting excellent antiviral activity, has emerged as a new candidate for antiviral agents. The current work provides a valuable reference for exploring the potential applications of ammosamide derivatives in plant protection. © 2025 Society of Chemical Industry.
Authors
- Zhenghong Zhou (ORCID: https://orcid.org/0000-0001-7753-4236)
- Hongying Tang (ORCID: https://orcid.org/0000-0002-1838-0748)
- Aidang Lu (ORCID: https://orcid.org/0000-0002-2255-8828)
- Qingmin Wang (ORCID: https://orcid.org/0000-0002-6062-3766)
- M. Li (ORCID: https://orcid.org/0009-0002-7945-3960)
- Ziwen Wang (ORCID: https://orcid.org/0000-0001-9798-7021)
- Mingjun Zhang (ORCID: https://orcid.org/0000-0002-3595-7043)
Institutions
- Tianjin Normal University (CN)
- Hebei University of Technology (CN)
- Nankai University (CN)
- Molina Center for Energy and the Environment (US)
- Collaborative Innovation Center of Chemical Science and Engineering Tianjin (CN)
Publication Details
- Journal
- Pest Management Science
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1002/ps.8748
- Citations
- 1
- Primary Topic
- Plant Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China