Myocardial Proteome in Human Heart Failure With Preserved Ejection Fraction
Integrative proteomics, transcriptomics, and pathway analysis supports a defect in both metabolism and translation in HFpEF. Patients with HFpEF with more distinct proteomic signatures from control more often had severe obesity, supporting therapeutic efforts targeting metabolism and translation, particularly in this subgroup.
Authors
- Jennifer E. Van Eyk (ORCID: https://orcid.org/0000-0001-9050-148X)
- Shirley A. Jenkin
- Jennifer T. Aguilan (ORCID: https://orcid.org/0000-0002-0221-354X)
- Aleksandra Binek (ORCID: https://orcid.org/0000-0001-5764-7137)
- Edwin Yoo (ORCID: https://orcid.org/0000-0003-4127-6313)
- Alina Guo (ORCID: https://orcid.org/0000-0002-6664-0145)
- Virginia S. Hahn (ORCID: https://orcid.org/0000-0002-0578-2668)
- Julie S. Kim (ORCID: https://orcid.org/0009-0004-2940-4241)
- Kavita Sharma (ORCID: https://orcid.org/0000-0002-3012-1765)
- Vivek Jani (ORCID: https://orcid.org/0000-0002-3811-4973)
- Mohammad Keykhaei (ORCID: https://orcid.org/0000-0001-5728-7848)
- Simone Sidoli (ORCID: https://orcid.org/0000-0001-9073-6641)
- David A. Kass (ORCID: https://orcid.org/0000-0003-1596-2299)
Institutions
- Cedars-Sinai Medical Center (US)
- Albert Einstein College of Medicine (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Cedars-Sinai Smidt Heart Institute (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1161/jaha.124.038945
- Citations
- 15
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 20.82