Identification of Long Noncoding RNA Candidate Disease Genes Associated With Clinically Reported Copy Number Variants in Congenital Heart Disease
Using weighted gene coexpression network analysis, we identified CNV-associated lncRNAs with potential relevance to CHD, underscoring the complexities of noncoding regions in disease pathogenesis. These findings suggest that lncRNAs may play a greater role in CHD than previously recognized, highlighting the need for broader genomic analyses that extend beyond protein-coding genes. This study provides a foundation for further exploration of lncRNAs in CHD, with potential implications for improved genetic characterization and diagnosis.
Authors
- Stephanie M. Ware (ORCID: https://orcid.org/0000-0003-4714-0142)
- Cecilia Lo (ORCID: https://orcid.org/0000-0003-4314-3434)
- Benjamin J. Landis (ORCID: https://orcid.org/0000-0001-5837-8581)
- Seema R. Lalani (ORCID: https://orcid.org/0000-0003-0707-657X)
- Vidu Garg (ORCID: https://orcid.org/0000-0002-3778-5927)
- Gabrielle C. Geddes (ORCID: https://orcid.org/0000-0003-2077-4997)
- Jeff Gaither (ORCID: https://orcid.org/0000-0003-1762-9414)
- Blythe Moreland (ORCID: https://orcid.org/0000-0002-7536-9537)
- Stephanie Burns Wechsler (ORCID: https://orcid.org/0000-0002-9321-0220)
- Kim L. McBride (ORCID: https://orcid.org/0000-0002-8407-8942)
- Jennelle C. Hodge (ORCID: https://orcid.org/0000-0002-1770-4042)
- Lindsey R. Helvaty (ORCID: https://orcid.org/0000-0002-4234-419X)
- Jiuann‐Huey Lin (ORCID: https://orcid.org/0000-0003-3029-6079)
- Jacqueline S. Penaloza (ORCID: https://orcid.org/0000-0003-0056-5434)
- Svetlana A. Yatsenko (ORCID: https://orcid.org/0000-0003-4809-8601)
- Peter White (ORCID: https://orcid.org/0000-0002-5218-5903)
Institutions
- Nationwide Children's Hospital (US)
- University of Calgary (CA)
- University School (US)
- Indiana University School of Medicine
- The Ohio State University (US)
- Indiana University (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1161/jaha.124.039177
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Nationwide Children's Hospital
- Children's Hospital Foundation
- Research Institute, Nationwide Children's Hospital