Mechanical Characterization and Feasibility Analysis of PolyJet™ Materials in Tissue-Mimicking Applications

PolyJet™ 3D printing is an additive manufacturing (AM) technology from StratasysTM. It has been used for applications such as tissue mimicking, printing anatomical models, and surgical planning. The materials available from StratasysTM have the inherent capabilities of producing a number of PolyJet™ materials with a range of physical properties that can be utilized for representing realistic tissue behavior mechanically. The preset materials available in the PolyJet™ printing software version 1.92.17.44384 GrabCADTM Print allow the user to manufacture materials similar to biological tissue, but the combinations of possibilities are limited and might not represent the broad spectrum of all tissue types. The purpose of this study was to determine the combination of PolyJet™ materials that most accurately mimicked a particular biological tissue mechanically. A detailed Design of Experiment (DOE) methodology was used to determine the combination of material mixtures and printing parameters and to analyze their mechanical properties that best matched the biological tissue properties available in the literature of approximately 50 different tissue types. Uniaxial tensile testing was performed according to the ASTM standard D638-14 of samples printed from Stratasys J850 digital anatomy printer to their determined stress–strain properties. The obtained values were subsequently validated by comparing them with the corresponding mechanical properties of biological tissues available in the literature. The resulting model, developed using the DOE approach, successfully produced artificial tissue analogs that span a wide range of mechanical characteristics, from tough, load-bearing tissues to soft, compliant tissues. The validation confirmed the effectiveness of the model in replicating the diverse mechanical behavior of various human tissues. Overall, this paper provides a detailed methodology of how materials and settings were chosen in GrabCADTM Print software and Digital Anatomy CreatorTM (DAC) to achieve an accurate artificial tissue material.