Features of microcirculatory disorders in patients with complicated diabetes mellitus

Objective. To assess microcirculatory disorders in patients with diabetic nephropathy and diabetic foot syndrome using the method of local skin thermometry. Materials and methods. 55 women with type 2 diabetes mellitus (group 1) (type 2 diabetes mellitus) with diabetic foot syndrome (DFS) and 261 patients with diabetic nephropathy (DN) (group 2) were examined. Control group (group 3) consisted of 125 patients without diabetes. The method of local skin thermometry was used to assess the microvasculature condition. Results. The response to local skin heating in patients with DFS differed from those of the control group. Vasodilation indices in the endothelial, neurogenic frequency range are inversely proportional to carbohydrate and lipid metabolism indicators. In patients with diabetes mellitus, carbohydrate metabolic disorders are associated with body mass index, duration of the disease, indicators of atherogenic fractions of the lipid spectrum and tactile sensitivity of the lower extremities. Conclusions. The response to local skin heating in patients with DFS differed from those of the control group and was characterized by an increase in vasodilation indices, in women with DN the ratio in endothelial and neurogenic frequency range was reduced. An inverse relationship between vasodilation indices and carbohydrate and lipid metabolism indicators was revealed.