Fluorine-Based Oxidant Enables Room-Temperature Pd-Catalyzed C–H Arylation with Boronic Acids

The biaryl motif is important in many fields within chemistry and the life sciences. Thus, better strategies to forge aryl-aryl bonds are valuable. Herein, we report conditions permitting the room temperature arylation of <i>N</i>-aryl amide substrates, using ubiquitous aryl boronic acid reagents. Critical to the success of this method is the use of Selectfluor as a sustainable alternative oxidant to silver-based additives and the deployment of a bulky QuinOx ligand supporting the palladium catalyst.