Risk factors of immune-related endocrine toxicities in non-small cell lung cancer patients treated with pembrolizumab and its impact on patient outcomes: a multicenter retrospective study
E-irAE are recognized as prevalent common irAE with various phenotypic manifestations. Low MLR and positive TGAb at baseline have been identified as risk factors that increase the likelihood of developing irTD. Sex and the occurrence of irTD were independently associated with improved PFS.
Authors
- Jianya Zhou (ORCID: https://orcid.org/0000-0001-8196-0166)
- Chenlin Ye
- Xiaoyu Wu (ORCID: https://orcid.org/0000-0003-2985-0917)
- Yuping Li (ORCID: https://orcid.org/0000-0002-4527-2582)
- Jing Zheng (ORCID: https://orcid.org/0000-0001-7696-9991)
- Jianying Zhou (ORCID: https://orcid.org/0000-0002-0233-419X)
- Haoting Zhang
- Xiaodong Lv (ORCID: https://orcid.org/0009-0007-4432-0291)
- C. Ren
Institutions
- Ningbo University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Jiaxing University (CN)
- Guang Fu Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- BMC Pulmonary Medicine
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s12890-025-03570-8
- Citations
- 5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 5.23