Photocatalytic Regioselective Alkoxycarbonylation/Cyclization of 3-Aza-1,5-dienes: Access to Ester-Containing Pyrrolin-2-ones
A direct alkoxycarbonyl radical-induced cascade reaction of 3-aza-1,5-dienes with alkyl chlorooxoacetates is reported. With this approach, an extensive range of ester-containing pyrrolin-2-ones are synthesized through photocatalyzed alkoxycarbonylation/cyclization with 3-aza-1,5-dienes under mild conditions. Moreover, dehydrogenative aromatization can proceed with the same photocatalytic system.
Authors
- Jie Wu (ORCID: https://orcid.org/0000-0002-0967-6360)
- Zhipeng Zong
- Jianqiang Chen (ORCID: https://orcid.org/0000-0001-6911-1858)
- Wenlin Xie
- Yuping Xiong
Institutions
- Hunan University of Science and Technology (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Organic Chemistry (CN)
- Henan Normal University (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1021/acs.orglett.5c00694
- Citations
- 8
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 7.49
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Zhejiang Provincial Ten Thousand Plan for Young Top Talents
- Scientific Research Foundation of Hunan Provincial Education Department
- Natural Science Foundation of Zhejiang Province