Alterations in Adiponectin Expression in Models of Cigarette Smoke Extract-Induced Mouse Pulmonary Emphysema and Alveolar Epithelial Cell Injury
Intraperitoneal CSE treatment induced lung inflammation, airspace enlargement, and increased adiponectin expression in mice. CSE-exposed A549 cells showed reduced cell viability, upregulated proinflammatory genes, downregulated adiponectin genes. Adiponectin treatment further intensified these genes expressions, aligning with <i>in vivo</i> findings. Elevated adiponectin expression in alveolar epithelial cells suggests its potential role in the development of COPD by enhancing lung inflammation.
Authors
- Sorachai Srisuma (ORCID: https://orcid.org/0000-0002-6253-189X)
- Julalux Thongam
- Sukpattaraporn Ruangklai (ORCID: https://orcid.org/0000-0002-8606-7067)
- Poungpetch Hussarin
- Thanaporn Rungruang
- Siriporn Vongsaiyat Siriphorn
- Supitsara Thorsuwan
Institutions
- Siriraj Hospital (TH)
- Mahidol University (TH)
- Chulabhorn Hospital (TH)
- Rangsit University (TH)
Publication Details
- Journal
- COPD Journal of Chronic Obstructive Pulmonary Disease
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1080/15412555.2025.2477235
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00