Novel Leech Antimicrobial Peptides, Hirunipins: Real‐Time 3D Monitoring of Antimicrobial and Antibiofilm Mechanisms Using Optical Diffraction Tomography (Adv. Sci. 10/2025)
leech ANtimicrobiAl PePtidesThe image features that the antimicrobial peptide hirunipin 2, secreted from the salivary glands of the leech (Hirudo nipponia), kills multidrug-resistant bacteria by attacking their cell membranes and rupturing the cell membranes, as well as destroying mature biofilms already formed by the multidrug-resistant bacteria.In article number 2409803, Seongsoo Lee, Song Yub Shin, Sung-Jin Cho, and co-workers highlight hirunipin 2 as a promising candidate for developing new antibacterial, anti-inflammatory, and anti-biofilm therapies, and as an adjunct to antibiotics against multidrug-resistant bacterial infections.
Authors
- S. Dinesh Kumar (ORCID: https://orcid.org/0000-0003-1364-5054)
- Yam Prasad Aryal
- Sathiyamoorthy Subramaniyam (ORCID: https://orcid.org/0000-0002-6890-6437)
- Seongsoo Lee (ORCID: https://orcid.org/0000-0002-8012-9749)
- Song Yub Shin (ORCID: https://orcid.org/0000-0002-3030-7973)
- Chul Won Lee (ORCID: https://orcid.org/0000-0002-3205-675X)
- Younhee Shin (ORCID: https://orcid.org/0000-0003-2002-044X)
- Geon‐Hwi Jeong
- Sung‐Hak Kim
- Naveen Kumar Radhakrishnan (ORCID: https://orcid.org/0000-0003-1478-2085)
- Sung–Jin Cho
- Jeongwon Park (ORCID: https://orcid.org/0000-0003-2891-4093)
- Sung‐Tae Yang (ORCID: https://orcid.org/0000-0002-5648-5938)
- Byambasuren Ganbaatar
- Yu‐jin Lim
- In‐Hyeok Pyo
Publication Details
- Journal
- Advanced Science
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/advs.202570068
- Citations
- 1
- Primary Topic
- Leech Biology and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.39