Optimal Timing of Exercise for Enhanced Learning and Memory: Insights From CA1 and CA3 Regions in Traumatic Brain Injury Model in Male Rats
Regular exercise or a consistent exercise routine before TBI, such as in athletes, may provide the most benefits from exercise intervention after the TBI. Starting exercise soon after the TBI (within 24 h) may help protect against brain edema and improve learning and memory by reducing cell death in specific brain regions (CA1 and CA3) and also decreasing TNF-α and MDA compared to starting exercise later (1 week after).
Authors
- Sara Shirazpour
- Mohammad Pourranjbar (ORCID: https://orcid.org/0000-0003-3624-0340)
- Mohammad Khaksari (ORCID: https://orcid.org/0000-0003-0770-4281)
- Sedigheh Amiresmaili (ORCID: https://orcid.org/0000-0002-7158-4096)
- Mohammad Amin Rajizadeh (ORCID: https://orcid.org/0000-0001-6708-1720)
- Elham Jafari (ORCID: https://orcid.org/0000-0001-9240-9177)
- Forouzan Rafie (ORCID: https://orcid.org/0000-0003-4242-4170)
- Amir Hossein Nekouei (ORCID: https://orcid.org/0009-0004-7986-4967)
- Omid Moradnejad
Institutions
- Emory University (US)
- Kerman University of Medical Sciences (IR)
- Bam University of Medical Sciences (IR)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/brb3.70354
- Citations
- 6
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 8.13