miR-34a-5p modulation of polycystic ovary syndrome via targeting the NOTCH signaling pathway
In summary, the miR-34a-5p molecule inhibits the growth of GCs as well as triggers programmed cell death by regulating the Jagged1-Notch signaling pathway. Silencing miR-34a-5p prevents dysfunction in GCs. Our analysis implies that miR-34a-5p is a new molecular site to treat PCOS.
Authors
- Yan Wang (ORCID: https://orcid.org/0000-0003-4940-0542)
- Hong Lin (ORCID: https://orcid.org/0000-0003-2884-7791)
- Min Zhao
- Lin Xu (ORCID: https://orcid.org/0000-0002-0537-922X)
- Yijing Chu (ORCID: https://orcid.org/0000-0002-4420-7084)
- Xiaofei Wang (ORCID: https://orcid.org/0000-0002-1266-5670)
- Xiaomeng Wang (ORCID: https://orcid.org/0000-0002-1036-2764)
- Fang Liu (ORCID: https://orcid.org/0000-0003-1707-5183)
- Kexin Zhang (ORCID: https://orcid.org/0000-0002-9224-9465)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Dazhou Central Hospital (CN)
- Qingdao Women and Children's Hospital (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s13048-025-01623-4
- Citations
- 5
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 4.68