TIMP2 rs2277698 polymorphism associated with adverse IVF outcomes in Han Chinese women
The study demonstrates that the minor T allele of TIMP2 (rs2277698 C/T) is associated with poor IVF outcomes, particularly non-live birth. This finding highlights the potential role of genetic variations in TIMP2 in influencing clinical outcomes of IVF. Further research is warranted to elucidate the underlying mechanisms in larger and more diverse populations.
Authors
- En‐Hui Cheng
- Shun‐Fa Yang (ORCID: https://orcid.org/0000-0002-0365-7927)
- Yu-Jen Lee (ORCID: https://orcid.org/0000-0003-1661-5643)
- Hui‐Mei Tsao (ORCID: https://orcid.org/0009-0000-9442-8638)
- Maw‐Sheng Lee (ORCID: https://orcid.org/0000-0001-6234-5432)
- Tsung‐Hsien Lee (ORCID: https://orcid.org/0000-0001-8858-0916)
- Chi‐Ying Lee (ORCID: https://orcid.org/0000-0002-9591-1370)
- Chun‐I Lee (ORCID: https://orcid.org/0000-0002-9267-5413)
- Chun‐Chia Huang (ORCID: https://orcid.org/0000-0003-2649-2384)
Institutions
- National Chung Hsing University (TW)
- National Tsing Hua University (TW)
- Chung Shan Medical University Hospital (TW)
- Taichung Hospital (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-03-13
- DOI
- https://doi.org/10.3389/fendo.2025.1542534
- Citations
- 1
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.77