Effect of a rehabilitation program on magnesium levels in women with vulvovaginal atrophy in surgical menopause

Background. Magnesium deficiency (MD) is a prevalent issue among women after radical treatment for gynecological cancers, particularly in the context of surgical menopause. A lack of magnesium can significantly affect the quality of life of patients, causing various somatic and psychological disorders. Objective: To assess the impact of a comprehensive “active” rehabilitation program on magnesium levels in women with vulvovaginal atrophy (VVA) in surgical menopause. Material and methods. The study included 140 women with VVA after radical treatment for female genital cancer. Participants were divided into two groups: Group 1 (n=70) received comprehensive “active” rehabilitation, while Group 2 (n=70) underwent standard rehabilitation. MD manifestations were evaluated at Months 1, 3, 6, and 12 after surgery using the Magnesium Deficiency Questionnaire (MDQ) and the Magnesium Deficiency Assessment Test (MDAT). Additionally, laboratory tests were performed to measure blood magnesium levels. Results. In the group receiving comprehensive “active” rehabilitation, a significant reduction in MD was observed as early as Month 1 (37.84±14.89 MDQ points compared to 65.10±26.30 points in the control group, p <0.01). By Month 3, symptoms of MD were nearly completely resolved (22.34±9.17 MDQ points). A similar trend was noted in MDAT results. Blood magnesium levels in Group 1 increased from 0.7±0.01 to 0.81±0.08 mmol/l at Month 1 and reached 0.90±0.06 mmol/l at Month 12. In contrast, the magnesium levels in Group 2 remained stable at 0.71–0.73 mmol/l throughout the study period. Conclusion. The comprehensive “active” rehabilitation program demonstrated high efficacy in correcting MD in women with VVA undergoing surgical menopause, contributing to an improvement in their quality of life.