Exosome‐Mediated Lectin Pathway and Resistin‐MIF‐AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia (Adv. Sci. 10/2025)
Immune ThrombocyTopenIaThe exosomes from patients with immune thrombocytopenia induce complement system activation through delivery of FCN2 and MBL2, triggering platelet destruction and hyperactivation of immune cells.The hyperactivated immune cells exploit resistin, MIF and arachidonic acid metabolism to enforce aberrant immune responses-akin to insurgents in hot-air balloons igniting rampant fires across a lightly guarded industrial zone, ultimately unleashing toxic chemical leaks.
Authors
- Yong Dong (ORCID: https://orcid.org/0000-0003-4058-3610)
- Baohong Yue (ORCID: https://orcid.org/0000-0001-6911-0177)
- Yingmei Li (ORCID: https://orcid.org/0000-0002-2333-595X)
- Rongqun Guo (ORCID: https://orcid.org/0000-0002-1238-4772)
- Liyan Fu
- Nannan Sun (ORCID: https://orcid.org/0000-0002-5255-9784)
- Huixia Yang (ORCID: https://orcid.org/0000-0001-8954-2102)
- Yanxia Gao (ORCID: https://orcid.org/0000-0001-5054-6624)
- Dawei Huo (ORCID: https://orcid.org/0000-0002-6144-7063)
- Yong Jiang (ORCID: https://orcid.org/0000-0001-7700-6054)
- Yan Xu (ORCID: https://orcid.org/0000-0001-8445-7996)
- Shuya Wang (ORCID: https://orcid.org/0000-0001-8766-5862)
- Xiaoqian Wang (ORCID: https://orcid.org/0000-0002-4424-6024)
- Huilin Zhang (ORCID: https://orcid.org/0000-0003-3045-7231)
- Mengyun Zhao (ORCID: https://orcid.org/0000-0001-7511-1678)
- Bo Qin (ORCID: https://orcid.org/0000-0002-4283-4041)
- Quande Lin (ORCID: https://orcid.org/0000-0002-8460-4674)
- Qingxuan Xin
- Jin Li
- Yaoyao Chen (ORCID: https://orcid.org/0009-0001-0169-1937)
- Xianlei Sun (ORCID: https://orcid.org/0009-0000-5183-699X)
- Fang Wang (ORCID: https://orcid.org/0000-0002-8808-8531)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/advs.202570066
- Citations
- 1
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.80