An Effective and Interpretable Sleep Stage Classification Approach Using Multi-Domain Electroencephalogram and Electrooculogram Features

Accurate sleep staging is critical for assessing sleep quality and diagnosing sleep disorders. Recent research efforts on automated sleep staging have focused on complex deep learning architectures that have achieved modest improvements in classification accuracy but have limited real-world applicability due to the complexity of model training and deployment and a lack of interpretability. This paper presents an effective and interpretable sleep staging scheme that follows a classical machine learning pipeline. Multi-domain features were extracted from preprocessed electroencephalogram (EEG) signals, and novel electrooculogram (EOG) features were created to characterize different sleep stages. A two-step feature selection strategy combining F-score pre-filtering and XGBoost feature ranking was designed to select the most discriminating feature subset, which was then fed into an XGBoost model for sleep stage classification. Through a rigorous double-cross-validation procedure, our approach achieved competitive classification performance on the public Sleep-EDF dataset (accuracy 87.0%, F1-score 86.6%, Kappa coefficient 0.81) compared with the state-of-the-art deep learning methods and provided interpretability through feature importance analysis. These promising results demonstrate the effectiveness of the proposed sleep staging model and show its potential in practical applications due to its low complexity, interpretability, and transparency.