Metrnl ameliorates myocardial ischemia–reperfusion injury by activating AMPK-mediated M2 macrophage polarization
Metrnl alleviates MI/RI by activating AMPK-mediated M2 macrophage polarization to attenuate inflammatory response and cardiomyocyte apoptosis. This study highlights the therapeutic potential of Metrnl in MI/RI, and identifies it as a promising target for the treatment of ischemic heart disease.
Authors
- Yang-Yi Feng
- Feng Huang (ORCID: https://orcid.org/0000-0003-1459-5394)
- Chuanghong Lu (ORCID: https://orcid.org/0000-0003-0332-4855)
- De-Zhao Liu
- Haiyan Wang (ORCID: https://orcid.org/0009-0002-4531-8744)
- Gong� Chen (ORCID: https://orcid.org/0000-0002-8036-3391)
- Na Na (ORCID: https://orcid.org/0000-0002-9394-8209)
- Yan Xue
- Dexin Chen (ORCID: https://orcid.org/0000-0002-1865-2862)
Institutions
- Scripps Research Institute (US)
- Guangxi Medical University (CN)
- Torrey Pines Institute For Molecular Studies (US)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s10020-025-01150-4
- Citations
- 11
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 12.81
Funders
- National Natural Science Foundation of China