Genome-wide screening in human embryonic stem cells identifies genes and pathways involved in the p53 pathway
Our study has identified two novel pathways that play a role in p53-mediated growth restriction. Moreover, we have highlighted the interaction between the Hippo and the p53 pathways. Interestingly, we have shown that TRIP12 plays an important function in the p53 pathway by selectively affecting its role as a transcription factor.
Authors
- Nissim Benvenisty (ORCID: https://orcid.org/0000-0001-8234-2685)
- Tamar Golan‐Lev
- Michal Goldberg (ORCID: https://orcid.org/0000-0001-9397-2383)
- Amir Haddad
Institutions
- Hebrew University of Jerusalem (IL)
- Jerusalem Institute for Israel Studies (IL)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s10020-025-01141-5
- Citations
- 1
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Rosetrees Trust
- Israel Cancer Association
- Israel Science Foundation
- Azrieli Foundation