Buffered salt solution versus 0.9% sodium chloride as fluid therapy for patients presenting with moderate to severe diabetic ketoacidosis: Study protocol for a Phase-3 cluster-crossover, blinded, randomised, controlled trial
The BEST-DKA trial commenced enrolment in March 2024 and should generate results that will determine whether treatment with Plasma-Lyte® 148, compared with saline, results in increased days alive, and out of hospital to day 28 for patients with moderate or severe DKA.
Authors
- Yasmine Ali Abdelhamid (ORCID: https://orcid.org/0000-0002-3340-1965)
- Elif Ilhan Ekinci (ORCID: https://orcid.org/0000-0003-2372-395X)
- Carolyn Koch
- Laurent Billot (ORCID: https://orcid.org/0000-0002-4975-9793)
- Simon R. Finfer (ORCID: https://orcid.org/0000-0002-2785-5864)
- Alexis Tabah (ORCID: https://orcid.org/0000-0003-3513-2778)
- John Myburgh (ORCID: https://orcid.org/0000-0003-4088-7016)
- Stacey Watts (ORCID: https://orcid.org/0000-0001-6729-016X)
- Benjamin Moran (ORCID: https://orcid.org/0000-0002-6515-6722)
- Séverine Bompoint
- Dorrilyn Rajbhandari
- Anthony Delaney (ORCID: https://orcid.org/0000-0002-1015-7146)
- Anthony Russell (ORCID: https://orcid.org/0000-0001-7886-8844)
- Anthony Devaux (ORCID: https://orcid.org/0000-0002-8862-4218)
- Alisa M. Higgins (ORCID: https://orcid.org/0000-0001-8295-7559)
- Antony George Attokaran (ORCID: https://orcid.org/0000-0001-6208-5116)
- Tessa Garside
- Gerben Keijzers (ORCID: https://orcid.org/0000-0003-1100-4552)
- Mahesh Ramanan (ORCID: https://orcid.org/0000-0003-4509-4015)
- Naomi E. Hammond (ORCID: https://orcid.org/0000-0002-6559-7747)
- Balasubramanian Venkatesh (ORCID: https://orcid.org/0000-0002-3234-5244)
- Qiang Li (ORCID: https://orcid.org/0000-0002-4384-8226)
- Priya Nair (ORCID: https://orcid.org/0000-0002-9771-7619)
- Jérémy Cohen (ORCID: https://orcid.org/0000-0003-4312-2537)
- Sandra Peake
Institutions
- Griffith University (AU)
- Bond University (AU)
- The University of Sydney (AU)
- The Royal Melbourne Hospital (AU)
- Queensland University of Technology (AU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- Royal Brisbane and Women's Hospital (AU)
- Royal North Shore Hospital (AU)
- Gold Coast Hospital (AU)
- Gosford Hospital (AU)
- UNSW Sydney (AU)
- St Vincent's Hospital Sydney (AU)
- Queen Elizabeth Hospital (AU)
- The George Institute for Global Health (AU)
- St George Hospital (AU)
- Redcliffe Hospital (AU)
- Austin Health (AU)
- Imperial College London (GB)
- Monash University (AU)
- The University of Adelaide (AU)
- University of Newcastle Australia (AU)
Publication Details
- Journal
- Critical Care and Resuscitation
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.ccrj.2025.100104
- Citations
- 2
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 2.33