Inhibition of PDE-4 and PDE-5 Differentially Modulates Isolated Porcine Urethral Contractility
The results from the study suggest a potential role of the cAMP pathway in modulating spontaneous contractions within the urethral mucosa, while the NO/cGMP pathway appears to be important in modulating urethral smooth muscle tonic contractions. These findings suggest differential roles of PDE isoenzymes in urethral tissues.
Authors
- Russ Chess‐Williams (ORCID: https://orcid.org/0000-0002-7991-4117)
- Iris Lim (ORCID: https://orcid.org/0000-0001-5866-8968)
- Donna Sellers (ORCID: https://orcid.org/0000-0002-0082-4216)
- Eriq Burovski
Institutions
- Bond University (AU)
- Université Bourgogne Franche-Comté (FR)
Publication Details
- Journal
- International Urogynecology Journal
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1007/s00192-025-06102-4
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00