Reviving hope: unlocking pancreatic islet immortality by optimizing a trehalose-based cryopreservation media and cell-penetrating peptide
Our findings accentuate the potential of trehalose and PLP as sophisticated cryoprotectants for preserving pancreatic islets. Beyond highlighting viability and functionality, the preserved islets demonstrated a remarkable capacity to restore euglycemia post-transplantation. This research holds promise in addressing the inherent limitations of islet transplantation, particularly in the realm of Type 1 diabetes treatment.
Authors
- Ensiyeh Hajizadeh‐Saffar
- Zakieh Samsonchi (ORCID: https://orcid.org/0000-0002-5001-7658)
- Roshanak Amirian (ORCID: https://orcid.org/0000-0001-9230-5175)
- Hossein Derakhshankhah (ORCID: https://orcid.org/0000-0002-0951-2729)
- Zhila Izadi (ORCID: https://orcid.org/0000-0002-4546-5202)
- Lobat Tayebi (ORCID: https://orcid.org/0000-0003-1947-5658)
Institutions
- Marquette University (US)
- Royan Institute (IR)
- Academic Center for Education, Culture and Research (IR)
- Kermanshah University of Medical Sciences (IR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s13287-025-04168-x
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Royan Institute
- Kermanshah University of Medical Sciences
- National Institute for Medical Research Development