Palladium-Catalyzed Directed Alkenylation of Alkyl Amides with Unactivated Alkenes: Access to γ-Alkenyl γ-Lactams
Pd(II)-catalyzed cascade C(sp<sup>3</sup>)-H alkenylation and cyclization of alkyl amides with readily accessible unactivated alkenes have been accomplished. Alkenylation and subsequent intramolecular cyclization empowered the formation of functionalized γ-lactams, which present as an active core of several bioactive and natural products. The use of catalytic Cu(OAc)<sub>2</sub> along with molecular oxygen as the oxidant, a 2-chloropyridine ligand, site selectivity, the substrate scope, and gram-scale synthesis are important practical features.
Authors
- Tharmalingam Punniyamurthy (ORCID: https://orcid.org/0000-0003-4696-8896)
- Santu Mandal (ORCID: https://orcid.org/0009-0000-7931-5918)
- Maniya V. Nanjegowda (ORCID: https://orcid.org/0009-0006-9015-9745)
- Madhab Barman
Institutions
- Indian Institute of Technology Guwahati (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1021/acs.orglett.5c00486
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- University Grants Commission
- Ministry of Education, India
- Science and Engineering Research Board