Characterization of insecticide resistance mechanisms in the Anopheles gambiae population of Sierra Leone
Malaria vectors were highly resistant to pyrethroids but exposure to PBO partially restored susceptibility in An. gambiae s.l. in Sierra Leone. Malaria vectors were susceptible to chlorfenapyr, clothianidin and pirimiphos-methyl with possible resistance to bendiocarb. These data informed the selection and distribution of ITN PBO in Sierra Leone's mass campaigns in 2020 and selection of clothianidin for indoor residual spraying in 2021.
Authors
- Kevin Opondo (ORCID: https://orcid.org/0000-0001-8975-6266)
- Evelyne Alyko
- Samuel J. Smith
- Laurent Iyikirenga
- Tony Hughes
- Yemane Yihdego
- Frederick Yamba
- Djenam Jacob
- A. Jalloh
- David Schnabel
- Miriam Mokuena
- Umaru Lolleh
- Ramlat Jose
- Samuel Conteh (ORCID: https://orcid.org/0009-0004-4481-0846)
- Rebecca Levine
- J. F. D. DONNELLY
Institutions
- Centers for Disease Control and Prevention (US)
- Njala University (SL)
- United States Agency for International Development (US)
- Ministry of Health and Sanitation (SL)
- U.S. President's Malaria Initiative (US)
- Navy and Marine Corps Force Health Protection Command (US)
- Abt Global (United States) (US)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s12936-025-05267-z
- Citations
- 5
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 9.39