Neuroimaging differences between chronic migraine with and without medication overuse headache: a 7 Tesla multimodal MRI study
Compared to CM - MOH patients, those with MOH exhibit distinct patterns of gray matter volume reduction in regions associated with memory and visual processing, accompanied by significant white matter disruption. Additionally, decreased spontaneous activity in the right putamen and heightened functional connectivity between the putamen and multiple brain regions are strongly correlated with the frequency of acute medication use. These results highlight the significant impact of medication overuse on brain structure and function, shedding light on the mechanisms of migraine chronification.
Authors
- Caohui Duan (ORCID: https://orcid.org/0000-0002-3470-5602)
- Xin Lou (ORCID: https://orcid.org/0000-0003-2980-5171)
- Zhao Dong (ORCID: https://orcid.org/0000-0002-4581-2569)
- Song Wang (ORCID: https://orcid.org/0000-0002-3457-6716)
- Lin Ma (ORCID: https://orcid.org/0000-0002-2911-3653)
- Yingyuan Liu
- Xiangbing Bian (ORCID: https://orcid.org/0000-0002-7016-6503)
- Shengyuan Yu (ORCID: https://orcid.org/0000-0001-8933-088X)
- Xinyu Wang (ORCID: https://orcid.org/0000-0002-3173-6390)
- Shuhua Zhang (ORCID: https://orcid.org/0000-0002-5748-0637)
- Xiu Liu (ORCID: https://orcid.org/0009-0009-7565-3157)
- Ruobing Wang (ORCID: https://orcid.org/0000-0002-2414-8777)
- Siyuan Xie (ORCID: https://orcid.org/0000-0001-8568-6627)
- Yin Sun (ORCID: https://orcid.org/0000-0003-2903-5410)
- Shuqing Wang
- Deqi Zhai
- Xiaoxue Lin (ORCID: https://orcid.org/0000-0001-6320-1991)
Institutions
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- Pingjin Hospital (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s10194-025-01988-3
- Citations
- 8
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 11.77
Funders
- National Natural Science Foundation of China