Bedaquiline Resistance and Treatment Outcomes Among Patients With Tuberculosis Previously Exposed to Bedaquiline in India: A Multicentric Retrospective Cohort Study
The study highlights a concerning rate of BDQ-resistance among previously treated patients, resulting in poor treatment outcomes. To prevent treatment failure, we recommend implementing BDQ-DST, developing affordable and accurate rapid tests for BDQ-resistance, and intensifying research and development efforts for newer TB drugs.
Authors
- Satish Devkota
- Vijay Chavan (ORCID: https://orcid.org/0000-0003-3563-6896)
- Pramila Singh (ORCID: https://orcid.org/0000-0002-4169-3937)
- Raman Mahajan (ORCID: https://orcid.org/0000-0001-6788-2835)
- Petros Isaakidis (ORCID: https://orcid.org/0000-0002-7881-1554)
- Mabel Morales
- Manpreet Bhalla (ORCID: https://orcid.org/0000-0002-8128-402X)
- Neeta Singla (ORCID: https://orcid.org/0000-0002-1340-3146)
- Ravindra Kumar Devan
- Homa Mansoor (ORCID: https://orcid.org/0000-0002-1793-6900)
- A Silsarma
- Gavish Kumar
- Rupak Singla (ORCID: https://orcid.org/0009-0004-4733-4013)
- Alpa Dalal
- Samsuddin Khan
- Hannah Spencer (ORCID: https://orcid.org/0009-0008-3715-8481)
- Aparna Iyer
Institutions
- University of Ioannina (GR)
- LRS Institute of Tuberculosis and Respiratory Diseases (IN)
- Jupiter Medical Center (US)
- Médecins Sans Frontières (GB)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1093/cid/ciaf068
- Citations
- 8
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 11.17