Clinical case of IgG4-associated disease with multi-organ involvement

Background. IgG4-related disease (IgG4-RD) is a rare immunomediated condition with a range of clinical manifestations that can include multi-organ involvement. This disease is often diagnosed incidentally and presents a significant risk to the cardiovascular system, making it a crucial subject for clinical research. Purpose – to present a clinical case of IgG4-RD with multi-organ involvement, particularly affecting the cardiovascular system, and to highlight the diagnostic and therapeutic challenges associated with limited access to specific laboratory tests. Materials and Methods. This article describes a case of a patient hospitalized with confirmed IgG4-RD. Diagnosis was based on clinical, laboratory, and instrumental data, using glucocorticoid therapy and other supportive treatments. Results. Glucocorticoid therapy resulted in a significant improvement in the patientʼs condition, reducing symptoms of internal organ involvement. Despite therapy, the disease led to irreversible organ damage due to diagnostic challenges linked to limited access to specific testing. Conclusions. This case highlights the difficulty of diagnosing and treating IgG4-RD, especially in settings with limited diagnostic resources. Awareness of the risk of multi-organ involvement and timely initiation of specific therapy are essential.