The Implementation and Impact of Chemical High-Throughput Experimentation at AstraZeneca
High-throughput experimentation (HTE) is a critical tool in modern pharmaceutical discovery and development. The ability to perform multiple parallel experiments in miniaturized plate-based formats has revolutionized how chemical reactions are optimized. HTE has been especially enabling for catalytic reactions, where the complexity of factors influencing the outcome makes the HTE approach especially suitable. We detail AstraZeneca’s 20-year journey with HTE, from early beginnings to a global community of HTE specialists that are critical to the delivery of our complex portfolio with reduced environmental impact. With an emphasis on catalytic reactions, we provide relevant case study examples from across discovery and development, discuss current technology, data science and workflows, and provide insights into where we see future advances in HTE.
Authors
- James J. Douglas (ORCID: https://orcid.org/0000-0002-9681-0459)
- Gary Fairley (ORCID: https://orcid.org/0000-0001-5541-5682)
- Zirong Zhang (ORCID: https://orcid.org/0000-0002-6720-4644)
- David Buttar (ORCID: https://orcid.org/0000-0001-5466-023X)
- Magnus J. Johansson (ORCID: https://orcid.org/0000-0002-0904-2835)
- Michele Tavanti (ORCID: https://orcid.org/0000-0002-7713-1899)
- Allyson C. McIntyre
- Erik Weis (ORCID: https://orcid.org/0000-0002-7845-4905)
- Thanh V. Q. Nguyen (ORCID: https://orcid.org/0000-0003-4320-0523)
- Simon D. Yates
- Rachel H. Munday (ORCID: https://orcid.org/0000-0002-1774-0529)
- Anthony J. Metrano (ORCID: https://orcid.org/0000-0002-2599-8917)
- Andrew D. Campbell (ORCID: https://orcid.org/0000-0002-0903-2426)
- Samantha Staniland
- Richard S. Morales
Institutions
- AstraZeneca (United Kingdom) (GB)
- AstraZeneca (Brazil) (BR)
- Université Bourgogne Franche-Comté (FR)
- Pharmaceutical Product Development (India) (IN)
- AstraZeneca (United States) (US)
Publication Details
- Journal
- ACS Catalysis
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1021/acscatal.4c07969
- Citations
- 21
- Primary Topic
- Radioactive element chemistry and processing
- Type
- article
- Field-Weighted Citation Impact
- 11.29