Basal cell adhesion molecule (BCAM) promotes mesothelial-to-mesenchymal transition and tumor angiogenesis through paracrine signaling
We have identified previously unknown functions of the BCAM-induced secretome potentially impacting distinct stages of OC metastasis. While BCAM's impact on MMT may facilitate initiation of micrometastases, neo-angiogenesis is essential for tumor growth. Taken together with the observed clinical adverse association, our findings underscore the potential of BCAM as a therapeutic target.
Authors
- Katrin Roth (ORCID: https://orcid.org/0000-0002-3144-1162)
- Sabine Müller‐Brüsselbach
- Julia Teply‐Szymanski (ORCID: https://orcid.org/0000-0002-3880-1968)
- Florian Finkernagel (ORCID: https://orcid.org/0000-0002-1141-7499)
- Silke Reinartz (ORCID: https://orcid.org/0009-0002-2851-193X)
- Raimund Dietze
- Vanessa M. Beutgen (ORCID: https://orcid.org/0000-0002-3354-2020)
- Andrea Nist (ORCID: https://orcid.org/0000-0002-7524-6801)
- Rolf Müller (ORCID: https://orcid.org/0000-0003-3339-4248)
- Thorsten Stiewe (ORCID: https://orcid.org/0000-0003-0134-7826)
- Sonja Lieber
- Johannes Graumann (ORCID: https://orcid.org/0000-0002-3015-5850)
- Suresh Sivakumar (ORCID: https://orcid.org/0000-0002-5711-0871)
- S R Heidemann
- Eileen C. Sutor
Institutions
- Philipps University of Marburg (DE)
- Justus-Liebig-Universität Gießen (DE)
- German Center for Lung Research (DE)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s12964-025-02128-9
- Citations
- 3
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Philipps-Universität Marburg