MiR-451a attenuates hepatic steatosis and hepatitis C virus replication by targeting glycerol kinase
These findings suggest that the alteration in the hepatic lipid profile upon HCV/HBV infection is attributed to the downregulation of miR-451a, which has the potential to restrict the expression of GK and SREBP1 in the TG biosynthesis pathway, implying that supplementation of miR-451a may be a potential therapeutic strategy for impeding CHC.
Authors
- Abhijit Chowdhury (ORCID: https://orcid.org/0000-0001-9198-4436)
- Soma Banerjee (ORCID: https://orcid.org/0000-0003-1828-9810)
- Swagata Majumdar (ORCID: https://orcid.org/0000-0001-7646-3990)
- Simanti Datta (ORCID: https://orcid.org/0000-0002-1584-6952)
- Deepshikha Chowdhury (ORCID: https://orcid.org/0000-0002-3925-2980)
- Bidhan Chandra Chakraborty
Institutions
- Institute of Post Graduate Medical Education and Research (IN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s12967-025-06286-9
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Indian Council of Medical Research