Novel GAL7-targeted fluorescent molecular imaging probe for high-grade squamous intraepithelial lesion and cervical cancer screening
Our study identified GAL7 as a specific target for CESC and successfully developed the GAL7-FITC fluorescence imaging probe. GAL7-FITC has shown promising potential for clinical application in the early detection of HSIL and CESC, providing rapid fluorescence imaging diagnosis without observable toxicity. This advancement may significantly enhance the accuracy and speed of cervical cancer diagnostics, ultimately improving patient outcomes.
Authors
- Kunshan He (ORCID: https://orcid.org/0000-0002-9629-5901)
- Chu Tang (ORCID: https://orcid.org/0000-0001-6899-8055)
- Xiaohui Teng (ORCID: https://orcid.org/0000-0002-8250-9198)
- Jie Tian (ORCID: https://orcid.org/0000-0003-0498-0432)
- Chunlin Chen (ORCID: https://orcid.org/0000-0002-1708-3047)
- Yang Du (ORCID: https://orcid.org/0000-0002-1564-1842)
Institutions
- Xidian University (CN)
- Xiamen University (CN)
- Chinese Academy of Sciences (CN)
- Shandong Institute of Automation (CN)
- Nanfang Hospital (CN)
- University of Chinese Academy of Sciences (CN)
- Southern Medical University (CN)
- Beihang University (CN)
- Ministry of Industry and Information Technology (CN)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s13550-025-01218-6
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Fujian Provincial Health Technology Project