Pretreatment Liquid Biopsy and Clinicopathologic Features in HPV−Associated Oropharyngeal Squamous Cell Carcinoma
This cohort study found that higher pretreatment TTMV-HPV DNA fragment levels were associated with more advanced clinical staging and higher aggregate primary and cervical nodal volume on PET-CT results. Future studies are needed to explore how pretreatment fragment level may influence treatment decisions.
Authors
- Kunal K. Sindhu (ORCID: https://orcid.org/0000-0001-9376-8307)
- Nasrin Ghesani
- Michael H. Berger (ORCID: https://orcid.org/0000-0002-1219-141X)
- Eric Michael Genden (ORCID: https://orcid.org/0000-0002-9707-0667)
- Raksha Kulkarni
- Daniel O. Kraft (ORCID: https://orcid.org/0000-0002-9107-9150)
- Peter V. Cooke (ORCID: https://orcid.org/0000-0002-3779-2027)
- Austin S. Lam (ORCID: https://orcid.org/0000-0002-2297-6376)
- Rocco M. Ferrandino (ORCID: https://orcid.org/0000-0003-2092-0296)
- Krzysztof J. Misiukiewicz (ORCID: https://orcid.org/0000-0001-9500-1484)
- Min Tang (ORCID: https://orcid.org/0000-0001-9990-0292)
- Catharine Kappauf (ORCID: https://orcid.org/0000-0001-7459-6298)
- Sida Chen (ORCID: https://orcid.org/0000-0002-6331-8695)
- Richard L. Bakst (ORCID: https://orcid.org/0000-0001-9279-7878)
- Scott A. Roof (ORCID: https://orcid.org/0000-0003-4881-0910)
- Raymond Liu Chai (ORCID: https://orcid.org/0000-0002-3582-4929)
- Marshall R. Posner (ORCID: https://orcid.org/0000-0003-1912-3281)
- Susmita Chennareddy (ORCID: https://orcid.org/0000-0002-0503-6876)
Institutions
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- JAMA Otolaryngology–Head & Neck Surgery
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1001/jamaoto.2024.5549
- Citations
- 5
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 9.24