Decreased adenosine 3′,5′-cyclic monophosphate is a driving factor of P300/SIRT1-mediated histone hyperacetylation in obesity-related hypertension
The reduced cAMP signaling pathway in obesity could promote histone 3 lysine 27 acetylation modification and upregulate ACE1 expression by regulating P300 and SIRT1 levels, which may have important implications in the management of obesity-related hypertension.
Authors
- Xiaodong Sun (ORCID: https://orcid.org/0000-0003-1279-7742)
- Haojie Wu
- Lin Shi (ORCID: https://orcid.org/0000-0001-7578-7440)
- Yuting Wang (ORCID: https://orcid.org/0000-0003-2347-2417)
- Qin Zhang (ORCID: https://orcid.org/0000-0002-4597-7697)
- Hui Wang (ORCID: https://orcid.org/0000-0003-1450-6320)
- Yaqi Li (ORCID: https://orcid.org/0000-0002-6829-8208)
- Chen Shen (ORCID: https://orcid.org/0000-0002-7806-5723)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Capital Institute of Pediatrics (CN)
- Children's Hospital of Capital Institute of Pediatrics (CN)
Publication Details
- Journal
- Journal of Hypertension
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1097/hjh.0000000000003981
- Citations
- 3
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 3.67