Target inhibition of SPAK in choroid plexus attenuates T cell infiltration and demyelination in experimental autoimmune encephalomyelitis
Our findings demonstrate that targeting ChP-SPAK signaling represents a novel therapeutic strategy for MS treatment.
Authors
- Zhongyue Lv (ORCID: https://orcid.org/0000-0002-8906-0629)
- Junxiao Hu (ORCID: https://orcid.org/0000-0002-5937-7916)
- Wu Zheng (ORCID: https://orcid.org/0000-0002-5091-9694)
- Chen-Xing Qi (ORCID: https://orcid.org/0000-0003-3288-0199)
- Yuyin Zheng (ORCID: https://orcid.org/0000-0003-4474-0775)
- Yiming Qiu (ORCID: https://orcid.org/0000-0003-2822-2468)
- Shujun Xu (ORCID: https://orcid.org/0009-0006-6832-5137)
- Yi Gu (ORCID: https://orcid.org/0000-0002-1220-7362)
- Xuhang Li (ORCID: https://orcid.org/0000-0002-9017-9002)
- Guomin Xie (ORCID: https://orcid.org/0000-0002-2579-1895)
- Yeping Wang (ORCID: https://orcid.org/0000-0002-8682-2456)
- Cheng Zheng (ORCID: https://orcid.org/0000-0003-1779-2676)
Institutions
- Ningbo University (CN)
- Wenzhou Medical University (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s12974-025-03407-5
- Citations
- 3
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Medical and Health Research Project of Zhejiang Province