Evaluation of Taste Acceptance of Three Different Fluoride Varnishes in Children with Autistic Spectrum Disorder: A Randomized Clinical Trial

<b>Background/Objective</b>: The taste perception of clinical materials used in dental treatment procedures can influence the compliance of autistic children during dental visits due to their heightened anxiety and sensory processing difficulties. This study aimed to evaluate the taste acceptance of different fluoride varnish preparations among children with autism spectrum disorder (ASD) in a clinical setting. <b>Methods</b>: This parallel-arm single-blinded randomized clinical study included autistic children aged 6-14 years, referred to a community dental clinic unit for preventive dental care. Non-verbal behavior, as a measure of taste acceptance, was assessed using the Frankl behavior rating scale. Additionally, subjective taste responses were recorded using a 3-point facial hedonic scale. Data were analyzed using descriptive statistics and the chi-square test. <b>Results</b>: There was no statistically significant difference in non-verbal behavior between the three fluoride varnish groups before application (<i>p</i> = 0.094) or immediately after application (<i>p</i> = 0.718). However, when comparing pre- and post-application responses within each group, Duraphat^® showed a significant improvement in non-verbal behavior (<i>p</i> = 0.020), while no significant changes were observed for Profluorid^® (<i>p</i> = 0.196) or MI Varnish^® (<i>p</i> = 0.704). Subjective taste acceptance, as measured by the 3-point facial hedonic scale, showed no significant differences among the varnish groups (<i>p</i> = 0.406). <b>Conclusions</b>: Flavored fluoride varnishes may improve the compliance of autistic children with preventive oral care procedures. Although no significant differences in taste acceptance were observed among the three varnishes, Duraphat^® was associated with a significant improvement in non-verbal positive behavior, suggesting a more favorable response in autistic children.