Antihyperalgesic effects of gabapentin and levetiracetam in a model of post-traumatic epilepsy
The presented study is the first to examine the effect of LEV and GBP in PTE. It was found that PTE decreased the thermal pain threshold, but LEV and GBP applied for 14 days prevented the decrease in PTE-related pain threshold and increased the thermal pain threshold. NAC, which was used as an adjuvant to support antiepileptic drugs, did not influence the thermal pain threshold alone; however, it increased the pain threshold more by potentiating the effect of LEV. Both LEV and GBP have an antihyperalgesic effect in the PTE model facilitated by PTZ, and NAC further reinforces the antihyperalgesic effect of LEV.
Authors
- Metehan Akça (ORCID: https://orcid.org/0000-0003-0500-920X)
- Cumaali Demirtaş (ORCID: https://orcid.org/0000-0001-5226-6730)
- Mustafa Efendioğlu (ORCID: https://orcid.org/0000-0003-3663-047X)
- Mehmet Yıldırım (ORCID: https://orcid.org/0000-0003-1798-5478)
- Duygu Ceman
- Recep Başaran
- Yunus Emre Sürmeneli
Institutions
- University of Health Science (KH)
- Tokat Gaziosmanpaşa Üniversitesi (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- Physiology International
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1556/2060.2025.00524
- Citations
- 2
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.99