Fc-mediated immune stimulating, pro-inflammatory and antitumor effects of anti-HER2 IgE against HER2-expressing and trastuzumab-resistant tumors
Collectively, anti-HER2 IgE maintains Fab-mediated antitumor activity, induces Fc-mediated effects against HER2-expressing tumor cells, and stimulates remodeling of the immune microenvironment in tumors to promote pro-inflammatory cell phenotypes which could translate to improved outcomes for patients.
Authors
- Heng Sheng Sow (ORCID: https://orcid.org/0000-0003-4143-7543)
- Alicia M. Chenoweth (ORCID: https://orcid.org/0000-0002-2736-9268)
- Gabriel Osborn (ORCID: https://orcid.org/0000-0003-1439-1973)
- Lais C. G. F. Palhares (ORCID: https://orcid.org/0000-0002-5558-1522)
- Heather J. Bax (ORCID: https://orcid.org/0000-0003-0432-4160)
- Jitesh Chauhan (ORCID: https://orcid.org/0000-0002-3968-9234)
- Elizabeth Hardaker
- Alexandra McCraw (ORCID: https://orcid.org/0009-0008-2412-4389)
- Sophia N. Karagiannis (ORCID: https://orcid.org/0000-0002-4100-7810)
- Rebecca Adams (ORCID: https://orcid.org/0000-0002-8378-9048)
- Jacobo López‐Abente (ORCID: https://orcid.org/0000-0003-3640-4077)
- Kristina M. Ilieva (ORCID: https://orcid.org/0000-0002-6877-3793)
- Sofia Vlasova
- Sophia Tsoka (ORCID: https://orcid.org/0000-0001-8403-1282)
- Katie Stoker (ORCID: https://orcid.org/0009-0002-7889-7164)
- James R. Birtley (ORCID: https://orcid.org/0000-0002-8159-4060)
- Melanie Grandits (ORCID: https://orcid.org/0000-0001-8143-8298)
- Kevin Fitzgerald
Institutions
- King's College London (GB)
- Breast Cancer Now (GB)
- Hammersmith Hospital (GB)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1136/jitc-2024-010945
- Citations
- 3
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 4.08
Funders
- Cancer Research UK
- British Skin Foundation
- Medical Research Council