SARS-CoV-2 genomic evolution during a severe and long-lasting omicron infection under antiviral therapy
This clinical case confirms the intra-host evolution dynamics of SARS-CoV-2 in an immunocompromised, prolonged-infected individual, involving positions associated with drug resistance and fusogenic traits of SARS-CoV-2. These results underscore the importance of the early detection of SARS-CoV-2 infection in immunocompromised individuals, and its rapid containment using highly effective treatment, to limit serious complications and the risk of new and potentially concerning viral variants emergence.
Authors
- Andrea Pastena
- Matteo Bolis
- Alessandro Parisi (ORCID: https://orcid.org/0000-0003-4629-7762)
- Arianna Liparoti
- Laura Alagna (ORCID: https://orcid.org/0000-0001-7022-8463)
- Sara Uceda Renteria (ORCID: https://orcid.org/0000-0002-2027-8478)
- Claudia Alteri (ORCID: https://orcid.org/0000-0003-4270-5079)
- Beatrice Zita Passerini (ORCID: https://orcid.org/0000-0002-2238-2148)
- Alessandra Bandera (ORCID: https://orcid.org/0000-0001-9440-4601)
- Antonio Muscatello (ORCID: https://orcid.org/0000-0002-2428-6432)
- Annapaola Callegaro
Institutions
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ospedale Maggiore (IT)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s12879-025-10740-w
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico