Non-classical monocytes are associated with functional markers of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction
LVDD and HFpEF are associated with a shift towards non-classical monocyte subtypes and higher numbers of non-classical monocytes are associated with signs of diastolic impairment. These findings highlight the importance of the inflammatory component in LVDD and HFpEF.
Authors
- Elisa Dal Canto (ORCID: https://orcid.org/0000-0001-8999-9946)
- Anne-Mar van Ommen
- Gideon Valstar (ORCID: https://orcid.org/0000-0003-0684-9622)
- Siroon Bekkering (ORCID: https://orcid.org/0000-0003-1149-466X)
- Daniek Kapteijn
- Frans Hendrik Rutten (ORCID: https://orcid.org/0000-0002-5052-7332)
- Leonard Hofstra (ORCID: https://orcid.org/0000-0003-4432-4720)
- Maarten J. Cramer (ORCID: https://orcid.org/0000-0002-6041-6759)
- Ernest Diez Benavente (ORCID: https://orcid.org/0000-0002-4313-4290)
- Roxana Menken (ORCID: https://orcid.org/0000-0002-6314-9238)
- Elise L. Kessler (ORCID: https://orcid.org/0000-0003-1974-4571)
- Michael J. Glade
- Arco J. Teske (ORCID: https://orcid.org/0000-0001-5305-1619)
- Hester M. den Ruijter (ORCID: https://orcid.org/0000-0001-9762-014X)
- Saskia C.A. de Jager (ORCID: https://orcid.org/0000-0002-5233-0066)
- Saskia Haitjema
- Niels P. Riksen
Institutions
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
Publication Details
- Journal
- International Journal of Cardiology
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1016/j.ijcard.2025.133161
- Citations
- 4
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 5.55