Micro-Pointed Electrode Optimization for Platelet-RBC Separation via Dielectrophoresis: A Computational Approach with COMSOL and Fuzzy Logic

This abstract highlights the optimization of micro-pointed chip design through COMSOL Multiphysics modeling and MATLAB-Fuzzy Logic analysis to enhance platelet-RBC separation. The results emphasize the importance of fine-tuning operational parameters and showcase the potential of microfluidic systems for various medical applications. To separate the platelets from the RBCs, we used a different size-based micro-pointed electrode model and found that the blood's input velocity should be between 600 and 1000 μm/s, and the appropriate voltage to apply to the microfluidic chip should be between 4 and 7 V. When these input values are applied for a microchannel length of 720 μm, the microfluidic exit channel is subject to a maximum pressure of 5.8-6 Pa and a maximum velocity of 1.3-1.5 mm/s. These findings demonstrate the ideal circumstances needed to separate platelets from red blood cells.