Inhibition of ERK1/2 mediated activation of Drp1 alleviates intervertebral disc degeneration via suppressing pyroptosis and apoptosis in nucleus pulposus cells
By offering experimental evidence on the role and mechanism of Drp1 in IVDD, this study underscores the potential of Mdivi-1 as a therapeutic strategy for IVDD.
Authors
- Jiaoxiang Chen
- Kaiying Zhang
- Xuanzhang Wu
- Bin Li (ORCID: https://orcid.org/0000-0003-2945-4092)
- Fengyu Zhang (ORCID: https://orcid.org/0000-0001-8504-0770)
- Yan Lin (ORCID: https://orcid.org/0000-0003-2315-1744)
- Hui Wang
- Shenkai Su
Institutions
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Yuxian People's Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.jot.2025.01.013
- Citations
- 12
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 17.66
Funders
- Wenzhou Medical University
- Wenzhou Municipal Science and Technology Bureau
- Department of Health of Zhejiang Province
- Science and Technology Plan Project of Wenzhou, China
- Medical Science and Technology Project of Zhejiang Province