Lactate infusion improves cardiac function in a porcine model of ischemic cardiogenic shock
Lactate infusion improved cardiac function and myocardial mitochondrial respiration in a porcine model of CS. The hemodynamic effects included increased CO mediated through stroke volume increase. These favorable cardiovascular effects may benefit patients with CS.
Authors
- Kristoffer Berg‐Hansen (ORCID: https://orcid.org/0000-0002-5110-0656)
- Henrik Wiggers (ORCID: https://orcid.org/0000-0002-9753-4142)
- Hanne Berg Ravn (ORCID: https://orcid.org/0000-0003-4702-5195)
- Nigopan Gopalasingam (ORCID: https://orcid.org/0009-0006-6363-7406)
- Ole Kristian Lerche Helgestad (ORCID: https://orcid.org/0000-0003-3847-8758)
- Halvor Guldbrandsen (ORCID: https://orcid.org/0000-0003-0820-8247)
- Roni Nielsen (ORCID: https://orcid.org/0000-0001-9228-3869)
- Niels Moeslund (ORCID: https://orcid.org/0000-0003-0827-5263)
- Oskar Kjærgaard Hørsdal (ORCID: https://orcid.org/0000-0003-1009-3768)
- Jacob Eifer Møller (ORCID: https://orcid.org/0000-0003-2873-5845)
- Alexander Møller Larsen
- Mark Stoltenberg Ellegaard (ORCID: https://orcid.org/0009-0000-9279-6269)
Institutions
- University of Southern Denmark (DK)
- Aarhus University (DK)
- Odense University Hospital (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- North Denmark Region (DK)
Publication Details
- Journal
- Critical Care
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1186/s13054-025-05346-2
- Citations
- 7
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 4.72
Funders
- Aarhus Universitet
- Aarhus Universitetshospital
- Aase og Ejnar Danielsens Fond
- Novo Nordisk
- Snedkermester Sophus Jacobsen og Hustru Astrid Jacobsens Fond
- Sundhedsvidenskabelige Fakultet, Aarhus Universitet