Gastric mucosal CD8+TRM cells are recruited through CXCR5-CXCL13 axis in Helicobacter pylori infected subjects
Gastric mucosal CD8<sup>+</sup> tissue-resident memory T (CD8<sup>+</sup>T<sub>RM</sub>) cells are increased in Helicobacter pylori (H. pylori) infected subjects, but the characteristics and chemotactic mechanism of CD8<sup>+</sup>T<sub>RM</sub> cells remain unknown. We demonstrated that C-X-C chemokine receptor 5 (CXCR5) was upregulated on gastric mucosal CD8<sup>+</sup>T<sub>RM</sub> cells, and gastric CXCL13 was dominantly secreted by dendritic cells and macrophages in H. pylori infected subjects. Gastric mucosal CD8<sup>+</sup>T<sub>RM</sub> cells from CagA+ H. pylori infected subjects was increased and could secrete more IFN-γ and TNF-α to engage in local immune response. The number of gastric mucosal CD8<sup>+</sup>T<sub>RM</sub> cells and the expression of CXCL13 was elevated in H. pylori infected individuals with the development of gastric diseases. In conclusion, gastric mucosal CD8<sup>+</sup>T<sub>RM</sub> cells are increased from CagA+ H. pylori infected subjects and could be recruited through CXCL13-CXCR5 axis, which mainly release IFN-γ and TNF-α in H. pylori related immune response.
Authors
- Xu Yue (ORCID: https://orcid.org/0000-0002-8861-8192)
- Hanmei Yuan
- Jia Xie (ORCID: https://orcid.org/0000-0002-1474-6394)
- Tingting Xia (ORCID: https://orcid.org/0000-0001-9599-6899)
- Yi Ren (ORCID: https://orcid.org/0000-0002-3665-700X)
- Bin Li (ORCID: https://orcid.org/0009-0008-3791-0936)
- Zelin Zhang (ORCID: https://orcid.org/0000-0002-8065-0059)
- Chao Wu (ORCID: https://orcid.org/0000-0002-1331-2746)
- Jie Ning (ORCID: https://orcid.org/0000-0002-2063-7696)
Institutions
- Sun Yat-sen University (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- Cytokine
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1016/j.cyto.2025.156904
- Citations
- 2
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province