Effect of adjuvant cisternostomy on the prognosis of patients with severe traumatic brain injury: A single center’s retrospective study

This study evaluates the efficacy of adjuvant cisternostomy (AC) versus decompressive craniectomy (DC) in managing severe traumatic brain injury (sTBI). A single-center retrospective analysis of consecutive sTBI patients treated with AC or DC alone (2018-2019) revealed that the AC group exhibited significantly lower intracranial pressure and higher Glasgow Coma Scale scores compared with the DC group (P < .05). Cerebrospinal fluid and serum analyses demonstrated reduced interleukin-1β and nerve fiber layer levels in the AC group. In addition, the AC group required lower mannitol dosages and showed fewer postoperative complications. Six-month follow-up indicated a statistically higher rate of good prognosis in the AC group (P < .05). These findings suggest that AC is superior to DC in reducing intracranial pressure, mitigating neurological damage, and improving clinical outcomes in sTBI patients.

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Journal
Medicine
Published
2025-03-07
DOI
https://doi.org/10.1097/md.0000000000041699
Primary Topic
Traumatic Brain Injury and Neurovascular Disturbances
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article
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article

Effect of adjuvant cisternostomy on the prognosis of patients with severe traumatic brain injury: A single center’s retrospective study

Bin Wang, Qiquan Zhang, ShiQi Cheng, Raorao Yuan et al.
Medicine
Traumatic Brain Injury and Neurovascular Disturbances
article

Effect of adjuvant cisternostomy on the prognosis of patients with severe traumatic brain injury: A single center’s retrospective study

Bin Wang, Qiquan Zhang, ShiQi Cheng, Raorao Yuan, Peng Chen, Wei Qiang Wang, Wenxin Zheng, Dongdong Xu, Yi Zhuo, D. Shu
article en

Abstract

This study evaluates the efficacy of adjuvant cisternostomy (AC) versus decompressive craniectomy (DC) in managing severe traumatic brain injury (sTBI). A single-center retrospective analysis of consecutive sTBI patients treated with AC or DC alone (2018-2019) revealed that the AC group exhibited significantly lower intracranial pressure and higher Glasgow Coma Scale scores compared with the DC group (P < .05). Cerebrospinal fluid and serum analyses demonstrated reduced interleukin-1β and nerve fiber layer levels in the AC group. In addition, the AC group required lower mannitol dosages and showed fewer postoperative complications. Six-month follow-up indicated a statistically higher rate of good prognosis in the AC group (P < .05). These findings suggest that AC is superior to DC in reducing intracranial pressure, mitigating neurological damage, and improving clinical outcomes in sTBI patients.

MedicineVol. 104(10)
Nanchang University (CN), Jiujiang First People's Hospital (CN), Second Affiliated Hospital of Nanchang University (CN), County Hospital (GB)
Good health and well-being
Openalex Percentile: Top 92%
Traumatic Brain Injury and Neurovascular Disturbances
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Effect of adjuvant cisternostomy on the prognosis of patients with severe traumatic brain injury: A single center’s retrospective study — Bin Wang, Qiquan Zhang, et al. · Medicine (2025) | TGRS Research Map | TGRS