INFLUENCE OF AMINO ACID COMPOSITIONS ON SULFUR-CONTAINING AMINO ACIDS POOL AND THEIR METABOLITES IN THE BLOOD PLASMA OF RATS DURING INTERMITTENT ALCOHOL INTOXICATION

Background. One of the factors leading to disturbances in the amino acid pool is alcohol consumption. Onjective. Studying the effect of amino acid compositions on the sulfur-containing amino acids pool and their metabolites in the blood plasma of rats in case of intermittent alcohol intoxication. Material and methods. 52 albino rats with a weight 180-220 g were subjected to 1- and 4-days alcoholization in models of intermittent alcohol intoxication (IAI-1 and IAI-4, correspondingly). In presence of IAI-1 and IAI-4, amino acid compositions Tritarg and Titacin were administered intragastrically instead of water. The contents of free amino acids and biogenic amines were determined by HPLC. Results. The administration of Tritarg in IAI-4 was accompanied by a decrease in the concentrations of methionine and β-alanine but an increase in the levels of homoserine, cysteinyl-glycine and γ-glutamylcysteine in comparison with the control group. When Titacin was administered in presence of IAI-4 the methionine contents has decreased and the homoserine level has increased compared to the control group. Conclusions. The administration of the amino acid compositions Tritarg and Titacin is accompanied by levels normalization of a number of pool components of the sulfur-containing compounds in the blood plasma compared to IAI-4 and IAI-1.