Photodynamic and Photothermal Effects of MXene Ti₃C₂T_<i>x</i> Under 460/808 nm Light Against Methicillin‐Resistant <i>Staphylococcus aureus</i>

ABSTRACT The emergence and widespread development of drug‐resistant bacteria pose significant challenges to global public health. Methicillin‐resistant Staphylococcus aureus (MRSA) is one of the most typical multidrug‐resistant bacteria, capable of causing life‐threatening diseases and exhibiting insensitivity to multiple antibiotics. Therefore, the development of antibiotic‐independent antimicrobial approaches is critically important. MXene Ti 3 C 2 T x , a promising two‐dimensional nanomaterial, possesses both photothermal and photodynamic effects. In this study, we investigated the photodynamic and photothermal mechanism of MXene Ti 3 C 2 T x against MRSA under irradiation with two different light sources: 460 nm short‐wavelength blue light and 808 nm near‐infrared light. Here, we prepared a stable MXene Ti 3 C 2 T x nanosheet dispersion system and confirmed its effective antimicrobial activity against MRSA. Furthermore, we observed differences in the photothermal and photodynamic effects of MXene Ti 3 C 2 T x under different light sources. These findings provide a comprehensive understanding of the photoreactive properties of MXene Ti 3 C 2 T x and guide clinical strategies for treating MRSA infections.