Circulating lung cancer exosomes damage the niche of intestinal stem cells
We demonstrated that circulating exosomes derived from lung cancer could impair ISCs and alter their niche in mice, which further explained the interaction between lung cancer and the gastrointestinal tract. This study proposes a promising and novel therapy to overcome weight loss in patients by decreasing LCCDEs secretion and blocking their binding to the intestine, which might be a feasible therapeutic approach in future clinical practice.
Authors
- Dengqun Liu (ORCID: https://orcid.org/0000-0003-3135-8067)
- Xu Lu (ORCID: https://orcid.org/0000-0003-4892-5240)
- Wenjun Jiang (ORCID: https://orcid.org/0000-0003-3400-3536)
- Xudan Lei (ORCID: https://orcid.org/0000-0002-0345-4302)
- Xi Wang (ORCID: https://orcid.org/0000-0002-7572-6354)
- Zhenni Xu (ORCID: https://orcid.org/0009-0008-3478-4786)
- Ke Wang (ORCID: https://orcid.org/0000-0003-4447-0787)
- Lingxiao Huang (ORCID: https://orcid.org/0000-0001-7512-142X)
- Jianhua Feng (ORCID: https://orcid.org/0000-0003-1570-7626)
- Jin Zhou (ORCID: https://orcid.org/0000-0001-9984-7137)
- Junyi Zou
- Shubin Wang
Institutions
- Sichuan Cancer Hospital (CN)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.21037/tlcr-24-758
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00