HPV vaccine impact: genotype-specific changes in cervical pre-cancer share similarities with changes in cervical screening cytology
hrHPV type-specific CIN2/CIN3/AIS incidence decreased with statistical significance for vaccine types HPV16/18 and for HPV31 and HPV33. Although the HPV vaccine is highly beneficial and a top priority for preventing HPV-related cancer, the long-term vaccine impact in cohorts receiving the 4-valent HPV vaccine requires continued follow-up to assess genotype-specific distributions in the remaining CIN2+ lesions and cancers.
Authors
- Ruth McDonald
- Wim Quint (ORCID: https://orcid.org/0000-0001-8616-9410)
- Cosette M. Wheeler (ORCID: https://orcid.org/0000-0003-3229-5846)
- Nancy E. Joste
- Mark H. Stoler (ORCID: https://orcid.org/0000-0002-2784-1008)
- Michael Robertson (ORCID: https://orcid.org/0000-0001-8247-1057)
- Rachael Adcock (ORCID: https://orcid.org/0000-0003-2856-7108)
- Maurits N.C. de Koning
- Norah Torrez‐Martinez
- William C. Hunt
Institutions
- University of New Mexico Hospital (US)
- University of Virginia Health System (US)
- New Mexico Cancer Center (US)
- DDL Diagnostic Laboratory (NL)
- UNM Comprehensive Cancer Center
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1093/jnci/djaf055
- Citations
- 5
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 6.77