Myocardial Ketone Body Oxidation Contributes to Empagliflozin-Induced Improvements in Cardiac Contractility in Murine Heart Failure
The beneficial effects of empagliflozin on cardiac contractility in post-MI heart failure are attenuated in mice which are incapable of oxidizing the ketone body β-hydroxybutyrate in their hearts. These findings suggest that enhanced cardiac ketone body oxidation contributes to the cardioprotective effects of SGLT2i.
Authors
- Belend Mahmoud (ORCID: https://orcid.org/0000-0002-5703-248X)
- Suzanne N. Voorrips (ORCID: https://orcid.org/0000-0002-6604-6349)
- Huitzilihuitl Saucedo‐Orozco (ORCID: https://orcid.org/0000-0002-4156-6364)
- Pablo Sánchez-Aguilera (ORCID: https://orcid.org/0000-0001-9207-2500)
- B. Daan Westenbrink (ORCID: https://orcid.org/0000-0002-1362-7019)
- Herman H.W. Silljé (ORCID: https://orcid.org/0000-0003-3292-6302)
- Kirsten T. Nijholt
- Elisabeth M. Schouten (ORCID: https://orcid.org/0000-0001-9568-5345)
- Constantin L. Palm (ORCID: https://orcid.org/0009-0006-6044-1299)
- Salva R. Yurista (ORCID: https://orcid.org/0000-0001-9126-739X)
- Peter van der Meer
- Anna M. Feringa
Institutions
- University Medical Center Groningen (NL)
- Harvard University (US)
- University of Groningen (NL)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1002/ejhf.3633
- Citations
- 5
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- European Society of Cardiology