Two new pregnane C <sub>21</sub> steroids isolated from the roots of <i>Periploca forrestii</i>
Two new C<sub>21</sub> steroids periplosteroid A-B (<b>1-2</b>) and seven known C<sub>21</sub> steroids (<b>3</b>-<b>9</b>) were isolated from the stems and roots of <i>Periploca forrestii</i>, among them, compounds <b>5</b>, <b>6</b>, <b>8</b> and <b>9</b> were firstly isolated from this plant. The structures of periplosteroid A-B were identified by comprehensive spectroscopic analyses, including 1D-NMR, 2D-NMR, HR-ESI-MS, UV, and IR spectral data. The results of cytotoxic activity showed that all the isolates exhibited certain inhibitory activity on six kinds of human tumour cell lines (786-O, MKN-45, 5637, L-02, MCF7 and 293 T).
Authors
- Jun-you Jian
- Xiao‐Jiang Hao (ORCID: https://orcid.org/0000-0001-9496-2152)
- Chun‐Mao Yuan (ORCID: https://orcid.org/0000-0002-3550-161X)
- Wei Gu (ORCID: https://orcid.org/0000-0001-7181-1458)
- Jun Jin (ORCID: https://orcid.org/0000-0002-5018-144X)
- Lie‐Jun Huang (ORCID: https://orcid.org/0000-0002-4374-7169)
- Qian Liu (ORCID: https://orcid.org/0000-0001-6880-4599)
Institutions
- Guiyang Medical University (CN)
- Guizhou University (CN)
- Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1080/14786419.2025.2471831
- Primary Topic
- Phytochemistry and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China