Microbiota associated with caries and apical periodontitis: A next‐generation sequencing study
Bacterial community structure differed significantly between biofilm and root canal samples, but showed no significant differences among biofilm samples based on dental caries status. However, some taxa were shared among caries-affected lesions, including dentine and root canals. H. multisaccharivorax, O. uli, L. gasseri, Selenomonadaceae species and S. inopinata exhibited higher abundance in caries-affected dentine and root canals with primary apical periodontitis, suggesting that specific bacteria in caries-affected dentine play a crucial role in the development of root canal infections and the pathogenesis of primary apical periodontitis.
Authors
- Kee‐Yeon Kum (ORCID: https://orcid.org/0000-0002-3032-3498)
- Hiran Perinpanayagam (ORCID: https://orcid.org/0000-0001-6484-5932)
- Jin‐Woo Bae (ORCID: https://orcid.org/0000-0001-6433-5270)
- J.Y. Lee
- Jae‐Yun Lee (ORCID: https://orcid.org/0000-0001-7973-8128)
- Ok‐Jin Park
- Seung Hyun Han (ORCID: https://orcid.org/0000-0001-9418-9278)
- Yun‐Seok Jeong
- Euon Jung Tak
- Yeon‐Jee Yoo (ORCID: https://orcid.org/0000-0002-3931-7668)
Institutions
- Western University (CA)
- Seoul National University (KR)
- Kyung Hee University (KR)
- Seoul National University Dental Hospital (KR)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1111/iej.14218
- Citations
- 7
- Primary Topic
- Endodontics and Root Canal Treatments
- Type
- article
- Field-Weighted Citation Impact
- 12.53
Funders
- National Research Foundation of Korea